2020

Heuschkel, K. and Kuypers, K. P. C. (2020) Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review. Frontiers in Psychiatry 11.

Kuypers, K. P. C., Verkes, R. J., van den Brink, W., van Amsterdam, J. G. C., & Ramaekers, J. G. (2018). Intoxicated aggression: Do alcohol and stimulants cause dose-related aggression? A review. European Neuropsychopharmacology, doi: https://doi.org/10.1016/j.euroneuro.2018.06.001

Papaseit Fontanet, E., Pérez-Mana, C., de Sousa Fernandes Perna, E. B., Olesti, E., Mateus, J., Kuypers, K. P. C., Theunissen, E. L., Fonseca, F., Torrens, M., Ramaekers, J.G., de la Torre, R., and Farre, M. (2020). Mephedrone and alcohol interactions in humans, Frontiers in Pharmacology, Neuropharmacology, 10:1588doi:10.3389/fphar.2019.01588

2019

Mason, N. L., Dolder, P. C., and Kuypers, K. P. C. (20). Reported effects of psychedelic use on those with low well-being given various emotional states and social contexts, Drug science, policy and law

Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., and Kuypers, K. P. C. (2019). Self-rated effectiveness of microdosing with psychedelics for mental and physical health problems amongst microdosers, Frontiers in Psychiatry, 10, 672

Kettner, H., Mason, N. L., and Kuypers, K. P. C. (2019). Motives for classical and novel psychoactive substances use in psychedelic polydrug-users, Contemporary Drug Problems, 46, 304-320

Kuypers, K. P., Ng, L., Erritzoe, D., Knudsen, G. M., Nichols, C. D., Nichols, D. E., … Nutt, D. (2019). Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. Journal of Psychopharmacology. https://doi.org/10.1177/0269881119857204

Nadia R.P.W. Hutten, Laura Steenbergen, Lorenza S. Colzato, Bernhard Hommel, Eef L. Theunissen, Johannes G. Ramaekers, Kim P.C. Kuypers (2019) Cocaine enhances figural, but impairs verbal ‘flexible’ divergent thinking,European Neuropsychopharmacology, 29, 813-824, https://doi.org/10.1016/j.euroneuro.2019.06.003

Hutten N, Mason NL, Dolder PC, Kuypers, KPC. (2019) Motives and Side-Effects of Microdosing With Psychedelics Among Users. Int J Neuropsychopharmacol 22: 426-434.

Uthaug MV, Lancelotta R, van Oorsouw K, Kuypers, K. P. C., Mason, N., Rak, J. Šuláková, A. Jurok, R. Maryška, M. Kuchař, M. Páleníček, T. Riba, J. Ramaekers, J. G. (2019) A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology.

Stefan W. Toennes David Schneider Werner Pogoda Alexander Paulke Cora Wunder Eef L. Theunissen Kim P.C. Kuypers Eliza de Sousa Fernandes Perna Johannes G. Ramaekers (2019). Pharmacokinetic properties of 4‐fluoroamphetamine in serum and oral fluid after oral ingestion. Drug Test Anal. 2019; 11: 1028– 1034. https://doi.org/10.1002/dta.2595

Theunissen EL, Hutten NRPW, Mason NL, Toennes SW, Kuypers KPC, de Sousa Fernandes Perna EB, Ramaekers JG (2019) Neurocognition and subjective experience following acute doses of the synthetic cannabinoid JWH-018: a phase 1, placebo-controlled, pilot study. Br J Pharmacol 175: 18-28.

Kuypers, K. P. C. (2019). Psychedelic medicine: the biology underlying the persisting psychedelic effects. Med Hypotheses. doi: https://doi.org/10.1016/j.mehy.2019.02.029

Mason, N. L., Mischler, E., Uthaug, M. V., & Kuypers, K. P. C. (2019). Sub-Acute Effects of Psilocybin on Empathy, Creative Thinking, and Subjective Well-Being. J Psychoactive Drugs, 1-12. doi: 10.1080/02791072.2019.1580804

van Amsterdam, J. G. C., Ramaekers, J. G., Verkes, R.-J., Kuypers, K. P. C., Goudriaan, A. E., & van den Brink, W. (2019). Alcohol- and drug-related public violence in Europe. European Journal of Criminology, 0(0), 1477370819828324. doi: 10.1177/1477370819828324

Theunissen, E. L., Hutten, N. R. P. W., Mason, N. L., Toennes, S. W., Kuypers, K. P. C., &  Ramaekers, J. G. (2019) Neurocognition and Subjective Experience Following Acute Doses of the Synthetic Cannabinoid JWH-018: Responders Versus Nonresponders. Cannabis and Cannabinoid Research, 0(0), null. doi: 10.1089/can.2018.0047

Hurlemann, R., Scheele, D., Kinfe, T.M., Berger, R., Philipsen, A., Voncken, M., Kuypers, K. P. C, Schruers, K. (2019) Increased temporal discounting in social anxiety disorder normalizes after oxytocin treatment, Psychotherapy and Psychosomatics, 10.1159/000495259

2018

Dolder, P. C., de Sousa Fernandes Perna, E. B., Mason, N. L., Hutten, N.R. P. W., Toennes, S. W., Theunissen E. L., Ramaekers, J. G., & Kuypers, K. P. C. (2018). Independent elevation of peripheral oxytocin concentrations and reduction in cognitive empathy during 4‐fluoroamphetamine intoxication, Human Psychopharmacology, DOI: 10.1002/hup.2680

Uthaug, M. V., van Oorsouw, K., Kuypers, K. P. C., van Boxtel, M., Broers, N. J., Mason, N. L., . . . Ramaekers, J. G. (2018). Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution. Psychopharmacology, doi: 10.1007/s00213-018-4988-3

Kuypers, K. P. C., Verkes, R. J., van den Brink, W., van Amsterdam, J. G. C., & Ramaekers, J. G. (2018). Intoxicated aggression: Do alcohol and stimulants cause dose-related aggression? A review. European Neuropsychopharmacology, doi: https://doi.org/10.1016/j.euroneuro.2018.06.001

De Sousafernandes Perna, E. B., Theunissen, E. L. Dolder, P. C., Mason, E. L., Hutten, N.,Toennes, S. W., Kuypers, K. P. C., & Ramaekers, J. G. (2018). Safety profile and neurocognitive function following acute 4-fluoroamphetamine (4-FA) administration in humans. Frontiers in Pharmacology, 9, 713

Hutten, N. R. P. W., Kuypers, K. P. C., van Wel, J. H. P., Theunissen, E. L., Toennes, S. W., Verkes, R.-J. & Ramaekers, J. G. (2018). A single dose of cocaine enhances prospective memory performance. Journal of Psychopharmacology, 32, 883-892

Mason, N. L., & Kuypers, K. P. C. (2018). Mental health of a self-selected sample of psychedelic users and self-medication practices with psychedelics. Journal of Psychedelic Studies, 2(1), 45–52. doi: https://doi.org/10.1556/2054.2018.006

Kuypers, K. P. C., de Sousa Fernandes Perna, E. B., Dolder, P. C., Toennes, S. W., Theunissen, E. L., Mason, N. L., Hutten, N. R. P. W, & Ramaekers, J. G (2018). Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine. Psychopharmacology. 235, 2349-2356

Kuypers, K.P.C. (2018). Context-dependent emotional empathy in virtual reality. Advances in Social Sciences Research Journal, 5, doi.org/10.14738/assrj.54.4514

Kuypers, K.P.C. (2018). Out of the box: A psychedelic model to study the creative mind. Medical Hypotheses, 115, 13-16.

Kuypers, K. P. C., de la Torre, R., Farre, M., Xicota, L., de Sousa Fernandes Perna, E. B., Theunissen, E. L., & Ramaekers, J. G. (2018). Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter. Sci Rep, 8(1), 1061. doi: 10.1038/s41598-018-19618-1

Theunissen, E. L., Hutten, N. R. P. W., Mason, N. L., Toennes, S. W., Kuypers, K. P. C., de Sousa Fernandes Perna, E. B., & Ramaekers, J. G. (2018). Neurocognition and subjective experience following acute doses of the synthetic cannabinoid JWH-018: a phase 1, placebo-controlled, pilot study. British Journal of Pharmacology, 175(1), 18-28. doi: 10.1111/bph.14066

Haijen, E., Farre, M., de la Torre, R., Pastor, A., Olesti, E., Pizarro, N., Ramaekers, J. G., Kuypers, K. P. C. (2018). Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication. Psychopharmacology (Berl). doi: 10.1007/s00213-017-4787-2

Kuypers, K. P. C., de la Torre, R., Farre, M., Pizarro, N., Xicota, L., & Ramaekers, J. G. (2018). Erratum to: MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor. Psychopharmacology (Berl). doi: 10.1007/s00213-017-4708-4

Kuypers, K. P. C., de la Torre, R., Farre, M., Pizarro, N., Xicota, L., & Ramaekers, J. G. (2018). MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor. Psychopharmacology (Berl). doi: 10.1007/s00213-017-4699-1

2017

Jongen, S., Vermeeren, A., van der Sluiszen, N. N., Schumacher, M. B., Theunissen, E. L., Kuypers, K. P., Ramaekers, J. G. (2017). A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., "weaving") while driving at a blood alcohol concentration of 0.5 g/L. Psychopharmacology (Berl), 234(5), 837-844. doi: 10.1007/s00213-016-4519-z

Kuypers, K. P. C. (2017). Emotional Empathic Responses to Dynamic Negative Affective Stimuli Is Gender-Dependent. Frontiers in Psychology, 8(1491). doi: 10.3389/fpsyg.2017.01491

Kuypers, K. P. C., Dolder, P. C., Ramaekers, J. G., & Liechti, M. E. (2017). Multifaceted empathy of healthy volunteers after single doses of MDMA: a pooled sample of placebo-controlled studies. Journal of Psychopharmacology, 31(5), 589-598. doi: 10.1177/0269881117699617

Puxty, D. J., Ramaekers, J. G., de la Torre, R., Farré, M., Pizarro, N., Pujadas, M., & Kuypers, K. P. C. (2017). MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor. Frontiers in Pharmacology, 8(455). doi: 10.3389/fphar.2017.00455

2016

de Sousa Fernandes Perna EB, Papaseit E, Perez-Mana C, Mateus J, Theunissen EL, Kuypers K, de la Torre R, Farre M, Ramaekers JG (2016) Neurocognitive performance following acute mephedrone administration, with and without alcohol. J Psychopharmacol. DOI: 10.1177/0269881116662635

Kuypers K, Riba J, de la Fuente Revenga M, Barker S, Theunissen E, Ramaekers J (2016). Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking. Psychopharmacology (Berl): 1-9.

Perna EDSF, Theunissen E, Kuypers K, Toennes S, Ramaekers J (2016). Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure. Psychopharmacology (Berl): 1-10.

Farré M, Perez-Maña C, de Souza E, Mateus J, Theunisen E, Kuypers K, et al (2016). Interactions between mephedrone and alcohol in humans: Cardiovascular and subjective effects. Eur Psychiatry 33: S115.

Kuypers KP, Theunissen EL, van Wel JH, Perna EBdSF, Linssen A, Sambeth A, et al (2016). Verbal Memory Impairment in Polydrug Ecstasy Users: A Clinical Perspective. PLoS One 11(2): e0149438.

Ramaekers J, van Wel J, Spronk D, Toennes S, Kuypers K, Theunissen E, et al (2016). Cannabis and tolerance: acute drug impairment as a function of cannabis use history. Scientific reports 6.

Sousa Fernandes Perna EB, Theunissen EL, Kuypers KP, Evers EA, Stiers P, Toennes SW, et al (2016). Brain reactivity to alcohol and cannabis marketing during sobriety and intoxication. Addict Biol.

2015

Kuypers, K. P. C., Steenbergen, L., Theunissen, E. L., Toennes, S. W. Ramaekers, J. G. (2015). Emotion recognition during cocaine intoxication. European Neuropsychopharmacology, http://dx.doi.org/10.1016/j.euroneuro.2015.08.012

Yubero-Lahoz, S., Kuypers, K. P. C., Ramaekers, J. G., Langohr, K., Farré, M., & de la Torre, R. (2015). Changes in serotonin transporter (5-HTT) gene expression in peripheral blood cells after MDMA intake. Psychopharmacology, 232, 1921-1929

van Heugten-Van der Kloet, D., Giesbrecht, T., van Wel, J., Bosker, W. M., Kuypers, K. P. C., Theunissen, E. L., Spronk, Desirée B., Verkes, R. J., Merckelbach, H., & Ramaekers, J. G. (2015). MDMA, cannabis, and cocaine produce acute dissociative symptoms. Psychiatry research, 228, 907-912

van Wel, J. H. P., Spronk, D. B., Kuypers, K. P. C., Theunissen, E. L., Toennes, S. W., Verkes, R. J., & Ramaekers, J. G. (2015). Psychedelic symptoms of cannabis and cocaine use as a function of trait impulsivity. Journal of Psychopharmacology, 29, 324-334

Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W., & Ramaekers, J. G. (2015). Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans. Psychopharmacology, 232, 343-353

2014

de Sousa Fernandes Perna, E. B., Theunissen, E. L., Kuypers, K. P. C., Heckman, P., de la Torre, R., Farre, M., & Ramaekers, J. G. (2014). Memory and mood during MDMA intoxication, with and without memantine pretreatment. Neuropharmacology, 87, 198-205

Kuypers KPC, de la Torre R, Farre M, Yubero-Lahoz S, Dziobek I, van den Bos W, et al (2014). No evidence that MDMA-induced enhancement of  emotional empathy is related to peripheral oxytocin levels or 5-HT1a receptor activation. PLoS One 9(6): e100719.

2013

Van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Toennes, S. W. Spronk, D. B., Verkes, R. J., Ramaekers, J. G. (2013).Single doses of THC and cocaine decrease proficiency of impulse control in heavy cannabis users. British Journal of Pharmacology, 170 (7), 1410-1420

Van de Ven, V., Wingen, M., Kuypers, K. P. C., Ramaekers, J. G., & Formisano, E. (2013). Escitalopram decreases cross-regional functional connectivity within the default-mode network. PLoS ONE, 8, e68355

Ramaekers, J. G., Evers, E. A., Theunissen, E. L., Kuypers, K. P. C., Goulas, A., & Stiers, P. (2013). Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit, Psychopharmacology, doi: 10.1007/s00213-013-3105-x

Bosker, W. M., Karschner, E. L. Lee, D., Goodwin, R. S., Hirvonen, J., Innis, R. B., Theunissen, E. L., Kuypers, K. P. C., Huestis, M. A., & Ramaekers, J. G. (2013). Psychomotor function in chronic daily cannabis smokers during sustained abstinence, PLoS ONE, 8 (1), e53127

Kuypers, K. P. C., de la Torre, R., Farre, M., Pujadas, M., Ramaekers, J. G. (2013). Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory, British journal of pharmacology, 168, 607-617

2012

Kuypers, K. P. C., Legrand, S.-A., Ramaekers, J. G., & Verstraete, A. G. (2012). A Case-Control Study Estimating Accident Risk for Alcohol, Medicines and Illegal Drugs, PLoS ONE, 7 (8), e43496

Ramaekers, J. G., Kuypers, K. P. C., Bosker, W. M., Brookhuis, K. A., Veldstra, J. A., Simons, R., Martens, M., Hjälmdahl, M., Forsman, A., & Knoche, A. (2012). Effects of stimulant drugs on actual and simulated driving: perspectives from four experimental studies conducted as part of the DRUID research consortium, Psychopharmacology, 222 (4), 413-418

Bosker, W. M., Kuypers, K. P. C., Conen, S., Kauert, G. F., Toennes, S. W., Skopp, G., & Ramaekers, J. G. (2012). MDMA (ecstasy) effects on actual driving performance before and after sleep deprivation, as function of dose and concentration in blood and oral fluid, Psychopharmacology, 222 (3), 367-376

Bosker, W. M., Theunissen, E. L., Conen, S., Kuypers, K. P. C., Jeffery, W. K., Walls, H. C., Kauert, G. F., Toennes, S. W., Moeller, M. R., & Ramaekers, J. G. (2012). A placebo-controlled study to assess Standardized Field Sobriety Tests performance during alcohol and cannabis intoxication in heavy cannabis users and accuracy of point collection testing devices for detecting THC in oral fluid, Psychopharmacology, 223 (4), 439-446

Bosker, W. M., Kuypers, K. P. C., Theunissen, E. L., Surinx, A., Blankespoor, R. J., Skopp, G., Jeffery, W. K., Walls, H. C., van Leeuwen, C. J., & Ramaekers, J. G. (2012). Medicinal THC (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in standard field sobriety tests, Addiction, 107 (10), 1837-1844

Van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Bosker, W. M., Bakker, K., & Ramaekers, J. G. (2012). Effects of acute MDMA intoxication on mood and impulsivity: role of the 5-HT2 and 5-HT1 receptors, PLOS One, 7, 1-8

2011

Kuypers, K. P. C., Wingen, M., Formisano, E., & Ramaekers, J. G. (2011) MDMA intoxication and verbal memory performance: a placebo-controlled pharmaco-MRI study, Journal of Psychopharmacology, 25, 1053-1061

van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Bosker, W. M., Bakker, K., & Ramaekers, J. G. (2011). Blockade of 5-HT2 receptor selectively prevents MDMA induced verbal memory impairment. Neuropsychopharmacology, 36, 1932-1939

2010

Bosker, W.M., Kuypers, K.P.C., Conen, S., & Ramaekers, J. G. (2010). Dose-related effects of MDMA on psychomotor function and mood before, during and after a night of sleep loss. Psychopharmacology, 209, 69-76

2009

Ramaekers, J. G., Kuypers, K. P. C., Wingen, M., Heinecke, A., & Formisano, E. (2009). Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (Ecstasy) intoxication: an event-related fMRI study Neuropsychopharmacology, 34, 1641-1648

2008

Kuypers, K. P. C., Wingen, M., & Ramaekers, J. G. (2008). Memory and mood during the night and in the morning after repeated evening doses of MDMA. Journal of Psychopharmacology, 22, 895-903

Wingen, M., Kuypers, K. P. C., Van De Ven, V., Formisano, E. & Ramaekers, J. G. (2008). Sustained attention and serotonin: a pharmaco-fMRI study, Human Psychopharmacology: Clinical and Experimental, 23, 221-230

2007

Kuypers, K. P. C., Wingen, M., Limbert, N., Samyn, N., & Ramaekers, J. G. (2007). Acute effects of nocturnal doses of MDMA on measures of impulsivity and psychomotor performance throughout the night. Psychopharmacology, 192, 111-119

Kuypers, K. P. C., & Ramaekers, J. G. (2007). Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected. Psychopharmacology, 198, 557-563

Wingen, M., Kuypers, K. P. C., & Ramaekers, J. G. (2007). The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers. Psychopharmacology, 190, 391-400

Wingen, M., Kuypers, K. P. C., & Ramaekers, J. G. (2007). Selective verbal and spatial memory impairment after 5-HT1a and 5-HT2a receptor blockade in healthy volunteers pre-treated with an SSRI. Journal of Psychopharmacology, 21, 477-485

2006

Kuypers, K. P. C., Samyn, N., & Ramaekers, J. G. (2006). MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function. Psychopharmacology, 187, 467-475

Ramaekers, J. G., & Kuypers, K. P. C. (2006). Acute Effects of 3,4-Methylenedioxymethamphetamine (MDMA) on Behavioral Measures of Impulsivity: Alone and in Combination with Alcohol. Neuropsychopharmacology, 31, 1048-1055

Ramaekers, J. G., Kuypers, K. P., & Samyn, N. (2006). Stimulant effects of 3,4-methylenedioxymethamphetamine (MDMA) 75 mg and methylphenidate 20 mg on actual driving during intoxication and withdrawal. Addiction, 101, 1614-1621

Theunissen, E. L., Jonkman, L. M., Kuypers, K. P., & Ramaekers, J. G. (2006). A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance. Journal of Psychopharmacology, 20, 496-505

2005

Kuypers, K. P. C., & Ramaekers, J. G. (2005). Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine. Journal of Psychopharmacology, 19, 633-639

Address:

Faculty of Psychology and Neuroscience

Dept. of Neuropsychology and Psychopharmacology

Room A 2.743

Universiteitssingel 40

6229 ER Maastricht, NL

Phone:

+ 31 433881902

Email:

k.kuypers@maastrichtuniversity.nl

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Researcher Unique Identifier: http://orcid.org/0000-0001-7634-3809